Evaluation of
some hormones in female having breast cancer before and after radiotherapy
Methaq N.M., Asmaa H.S. and Atallah B.D.
Res. J. Biotech.; Vol. 19(7); 78-83;
doi: https://doi.org/10.25303/1907rjbt078083; (2024)
Abstract
Hormones are believed to largely affect cancer risk by controlling the rate of cell
differentiation, division and quantity of cancer-vulnerable cells. Higher estrogen
levels, progesterone, prolactin and serotonin have been linked to some cancers including
breast cancer. The study aims for a relationship between estrogen, progesterone,
prolactin and serotonin signaling and breast cancer to shed light on the pivotal
role of hormonal imbalance in the development of breast cancer. The study included
50 new female patients with breast cancer, they do not have diseases related to
hormones. Patients were followed up and blood samples were taken for the same group
of patients when treated with radiation at the fifth and fifteenth doses (patients,
R5, R15) with 50 samples of apparently healthy females as comparison group (control),
The ages of the patients and healthy people ranged between 25-70 years. Estrogen,
progesterone, prolactin and serotonin levels were tested and the results showed
a significant increase in the concentration of estrogen at the probability level
P˂0.0001 for the three groups (patients, R5, R15) 596.8±107.6 pg/mL, 561.8±103.1
pg/mL, 466.9±80.43 pg/mL respectively compared to the control group of healthy women
178.3±69.74 pg/mL.
The results indicated a significant increase in the concentrations of progesterone,
prolactin and serotonin at the probability level P˂0.0001 for the three groups (patients,
R5, R15) compared to the control group of healthy women and a significant decrease
in the concentration of the hormone estrogen, progesterone, prolactin and serotonin
at the probability level P˂0.0001 for the group of women treated at the R-15 dose
compared to the group of women treated at the dose R-5.
