Review Paper:
Drug designing:
Lifeline for the drug discovery and development process
Kaur Navneet, Akhter Mymoona and Singla Chhavi
Res. J. Chem. Environ; Vol. 26(8); 173-179;
doi: https://doi.org/10.25303/2608rjce1730179; (2022)
Abstract
Drug discovery and development field has entered into a revolutionary phase with
the introduction of Computer Aided Drug Designing (CADD) tools in the designing
and development of new drugs. Traditional drug discovery and designing is a tedious,
expensive and time-consuming process. Pharmaceutical industries spend billions of
dollars to launch a potential drug candidate into the drug market. It takes 15-20
years of research to discover a new drug candidate. The advancements in the Computer
Aided Drug Designing techniques have significantly contributed towards lowering
the cost and time involved in new drug discovery. Different types of approaches
are used to find out the potential drug candidates. Numerous compounds have been
successfully discovered and launched into the market using computational tools.
Various novel software-based methods like Structure- Based Drug Designing (SBDD),
Ligand-Based Drug Designing (LBDD), Pharmacophore Mapping and Fragment-Based Drug
Designing (FBDD) are considered as powerful tools for determining the pharmacokinetics,
pharmacodynamics and structure activity relationship between target protein and
its ligand. These tools provide valuable information about experimental findings
and the mechanism of action of drug molecules. This has greatly expedited the discovery
of promising drug candidates by sidestepping the lengthy steps involved in the synthesis
of unnecessary compounds.
