Research Journal of Chemistry

and Environment


Indexed in SCOPUS, Chemical Abstracts, UGC, NAAS, Indian Citation Index etc.



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Review Paper:

Nasal Drug Delivery System for Brain Targeting: A Potential Route

Devi Rajni and Devi Anjana

Res. J. Chem. Environ; Vol. 26(8); 180-189; doi: https://doi.org/10.25303/2608rjce1800189; (2022)

Abstract
Targeted drug delivery aims to concentrate medication in the target tissues while lowering the relative concentration in the remainder of the body. As a result, the drug's efficacy and adverse effects are improved. The Blood brain barrier prevents possible therapeutic molecules from reaching the brain. Approximately 1.5 billion people suffer from CNS illnesses which must be treated with effective drug delivery to the brain. Alzheimer's disease, Parkinson's disease, Huntington's disease, depression, anxiety, seizures, epilepsy, migraine and other CNS illnesses can now be efficiently treated using intranasal medication delivery to the brain. The intranasal route of administration allows for direct medication delivery to the brain without the need for systemic absorption, improving efficacy and reducing side effects in neurotherapeutics.

The olfactory and trigeminal neural pathways allow direct drug delivery to the brain over the BBB and this has become a popular method for delivering a wide spectrum of therapeutic molecules to the brain. When compared to other mucous membranes, the nasal mucosa is highly accessible and serves as a convenient entry point for tiny and big molecules. Intranasal administration has a quick beginning of action, no first-pass effect, no gastrointestinal or pulmonary toxicity and is non-invasive. It also increases bioavailability. This review will give ways for improving drug delivery to the brain via the nasal mucosa as well as recent clinical trials in this area.