Development of
spectrophotometric method for analysis of mercaptopurine and dimercaprol for use
in quality control and monitoring water pollution
Singh Jasvir
Res. J. Chem. Environ; Vol. 26(1); 34-40;
doi: https://doi.org/10.25303/2601rjce3440; (2022)
Abstract
In the present work, spectrophotometric method was developed for analysis of mercaptopurine
and dimercaprol to be applied in quality control and monitoring water pollution.
These drugs are used for the treatment of cancer and heavy metal poisoning respectively.
Both mercaptopurine and dimercaprol react with colourless anhydrous manganese (II)
acetate in DMSO to form soluble brown coloured complexes which showed λmax at 350
nm and 360nm during spectrophotometric analysis.
This newly developed method was successfully applied for analysis of commercial
drugs and spiked water. The recovery of these drugs from commercial formulations
and spiked water samples was in the range between 98.0-99.7% with RSDs in the range
0.56-1.50% that indicated high degree of accuracy and precision of the method.
