In vivo synergistic
antibiofilm activity of Curcumin Silver Nanoparticles against UTI causing colistin
resistance E.coli
Malathi S. and Jagathy K.
Res. J. Chem. Environ; Vol. 26(1); 53-57;
doi: https://doi.org/10.25303/2601rjce5357; (2022)
Abstract
Biofilm resilence has become a serious issue in the treatment of urinary tract infection
leading to the resistance to various antibiotics. There is a rapid need to develop
new antibacterial agents or amalgamation drug therapies. Silver nanoparticles (AgNPs)
are used as an anti-biofilm agent for the treatment of urinary tract infections.
Meanwhile curcumin, a phenolic plant extract is also acting as natural anti-biofilm
agent.
The objective of this study was to analyse the amalgamation of AgNPs and curcumin
nanoparticles (Cur-NPs) against gram-negative E.coli at 100 μg/mL. This disrupted
50% of established bacterial biofilms. Scanning electron microscopy (SEM) and confocal
laser scanning microscopy (CLSM) revealed that amalgamation therapy (Cur-SNPs) was
the most vigorous to destruct preformed biofilm.
