In vitro Evaluation
(Antioxidant Activity) of coumarin derivatives
Devi Sarika, Singh Pooja, Rathi Vaibhav and Kumar Praveen
Res. J. Chem. Environ; Vol. 26(7); 145-152;
doi: https://doi.org/10.25303/2607rjce145152; (2022)
Abstract
Coumarin is a heterocyclic molecule associated with beneficial human health effects
such as to reduce the risk of cancer, diabetes, cardiovascular and brain disease.
These effects are thought to be related to free radical scavenging due to their
antioxidant properties. Coumarin is a substance that has been synthesized in many
of its derivatives in recent years. This entity is a major source of interest for
many medicinal chemists to explore its various pharmacological possibilities, especially
anticoagulant activity.
The antioxidant activities of two synthesized coumarin derivatives namely 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N'-(1-(4-aminophenyl)ethylidene)
acetohydra zide [M1] and 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N'-(1-(2 hydroxy
phenyl) ethylidene) acetohydrazide [M2] were studied with the DPPH method. Structure
of two coumarin synthesized compounds is proposed on the basis of spectroscopic
evidence.
