Synthesis, molecular
docking and in vitro cytotoxicity studies of 3,5-dimetyl arylazo pyrazole derivatives
Aggarwal Natasha N., Gopika K.V. and Revanasiddappa B.C.
Res. J. Chem. Environ; Vol. 26(6); 38-44;
doi: https://doi.org/10.25303/2606rjce038044; (2022)
Abstract
A new series of 3,5-dimethyl-arylazopyrazoles (3a-h) was synthesized by reacting
various oxobutyrates (2) with 4-methoxy benzhydrazide (1) in glacial acetic acid
medium. The oxobutyrates were prepared by diazotization of substituted anilines
and subsequent condensation with acetyl acetone in the alcohol medium.
The new compounds were elucidated on the basis of IR, 1H-NMR and mass spectral data
and the compounds were screened for their in vitro cytotoxic activity using MDA-MB-231
and MCF-7 cell lines. Some of the tested compounds showed weak to moderate cytotoxic
effects.
