Ethoxyphathalimide
linked some 2, 4, 8-Triphenyl-4H-9-thia-1, 4a, 5, 7-tetraaza-fluoren-6-ylamine derivatives:
Synthesis and Pharmacological Evaluation from Chalcone
Prajapat Prakash, Kherodiya Bhawana and Talesara Ganpat L.
Res. J. Chem. Environ; Vol. 27(8); 48-54;
doi: https://doi.org/10.25303/2708rjce048054; (2023)
Abstract
Synthesis of benzalacetophenones (1a-c) has been achieved by the aldol condensation
of substituted acetophenone with benzaldehyde. These were treated with thiourea
by utilizing HCl to give substituted dihydropyrimidine-thiones (2a-c). Cyclization
of these compounds with DMF and chloroacetic acid yielded pyrimidothiazolidinone
moieties (3a-c). Reaction of benzaldehyde with 3a-c produced corresponding chalcone
derivatives (4a-c). These chalcone derivatives when treated with guanidine nitrate
in presence of a base gave (5a-c). Condensation of 5a-c with bromoethoxyphthalimide
afforded titled compounds (6a-c).
Structures of prepared scaffolds were established by the spectral studies, elemental
analysis and chemical tests. Subsequently, heterocyclic hybrids (5a-c, 6a-c) were
assayed to their in vitro anti-microbial activity against a variety of infectious
strains of bacteria and fungi.
