Synthesis of novel
benzimidazole clubbed pyrazole heterocycles derivatives as potentially antibacterial
agents
Hadiyal Ashvin and Bhatt Jyotindra
Res. J. Chem. Environ; Vol. 27(8); 123-129;
doi: https://doi.org/10.25303/2708rjce1230129; (2023)
Abstract
Some new derivatives of benzimidazole bearing pyrazole heterocycles 4a–o (2-(1H-benzo[d]
imidazol-1-yl)-1- (3, 5-diphenyl-4,5-dihydro-1H- pyrazol-1-yl) ethan-1-one) were
synthesized by simple synthetic protocol. The title compounds (4a-o) have been characterized
by infrared spectroscopy, 1H and 13C NMR spectroscopy and mass spectroscopy. Anti-bacterial
activity of synthesised compounds was carried out in which 3-nitro derivatives 4e
and 4o showed good activity against both Gram positive and Gram negative bacterial
strain in vitro.
Compound 4e was most potent against Gram negative bacteria (E. coli, MIZ= 21mm and
E. aerogenes, MIZ = 24mm) in comparison to amoxycilin (E. coli, MIZ= 16mm and E.
aerogenes, MIZ = 18mm) while compounds 4i (S. aureus, MIZ = 34mm;) and 4o (S. aureus
MIZ = 36mm) were most active against Gram-positive bacteria of the series.
