Novel carboxamide
and carbohydrazide functionalized pyridopyrimidine derivatives and their anticancer
activity
Dasari Raghu, Gali Srinivas and Vaddiraju Namrata
Res. J. Chem. Environ; Vol. 27(5); 83-90;
doi: https://doi.org/10.25303/2705rjce083090; (2023)
Abstract
A series of novel carboxamide and carbohydrazide functionalized pyridopyrimidine
derivatives was prepared starting from 6-methyl/ethyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile
1. Compound 1 on reaction with sulphuric acid gave compound 2. Compound 2 on reaction
with chloroacetamide followed by reaction with EMME coupling and further cyclization
gave compound 5. Compound 5 on reaction with hydrazine hydrate produced hydrazide
derivatives 6.
Compound 6 on reaction with diverse substituted aromatic aldehyde gave Schiff’s
base derivatives 7a-j. Ester derivatives 5 on reaction with different aliphatic
amine gave carboxamide derivatives 8a-f. All the final 7a-j and 8a-f compounds were
evaluated for anti cancer activity against four human cancer cell lines such as
HeLa - Cervical cancer (CCL-2), COLO 205- Colon cancer (CCL-222); HepG2- Liver cancer
(HB-8065), MCF7 - Breast cancer (HTB-22) and promising compounds 7e, 7h and 7j have
been identified.
