A Simple Colorimetric
Method for the Estimation of Metoclopramide Hydrochloride in Pharmaceuticals dosage
Al-Hafidh Hiba A. and Yassin Rabee M.A.
Res. J. Chem. Environ.; Vol. 28(8); 23-31;
doi: https://doi.org/10.25303/288rjce023031; (2024)
Abstract
A spectrophotometric method based on the use of diazotization and coupling reaction
was developed for the determination of metoclopramide hydrochloride (METH) by reacting
a nitrogenous drug complex (D-METH) with reagent 4-chlororesorcinol (4-CRS). The
alkaline dye gives a stable azoic red dye in the aqueous media, which gave the highest
absorption at the wavelength of 527 nm and the limits of Beer's law had a linear
relationship located within concentrations of 1-15 μg/ml and with a molar absorption
coefficient of 2.53 × 104 L/mol. cm.
Sandell's significance was 0.0140 μg/cm, while the LOD and LOQ values were 0.034
μg/ml and 0.114 μg/ml respectively. The proposed method has been successfully applied
in the determination of metoclopramide hydrochloride in its pharmaceutical preparations
in the form of tablets and injections.
