Biogenic Synthesis
of Gold Nanoparticles using Bark Extract of Bauhinia variegata: Antibacterial and
in vitro Anticancer study
Vaghela Hiral, Parmar Kokila and Mahyavanshi Jyotindra
Res. J. Chem. Environ.; Vol. 28(1); 48-56;
doi: https://doi.org/10.25303/281rjce48056; (2024)
Abstract
Our study revealed the biological synthesis of gold nanoparticles (AuNPs) using
aqueous bark extract of plant named Bauhinia variegata (Kaanchnar). Biomolecules
present in the plants act as a reducing and capping agent. In this reduction reaction,
gold (III) metal was reduced by biomolecules present in plants leading to formation
of AuNPs. Biosynthesized AuNPs were characterized by spectral analysis (XRD, FTIR,
UV-visible) and imaging microscopy. Antibacterial study of the biosynthesized AuNPs
was examined against Gram-positive (Bacillus subtilis) and Gram-negative (Escherichia
coli) bacteria using agar well diffusion method and AuNPs exhibited an excellent
inhibition zone against mentioned bacteria. In vitro anticancer study of AuNPs was
performed on MCF-7 cell line. Compared to standard drug, AuNPs exhibited potent
anticancer activity with the IC50 value 15.55 μg/ml.
