Novel triazolo
pyridine derivatives and their anti cancer activity
Kumara Swamy M. and Bhaskar K.
Res. J. Chem. Environ.; Vol. 28(1); 21-26;
doi: https://doi.org/10.25303/281rjce21026; (2024)
Abstract
A series of novel triazole functionalized trifluoromethyl pyridine derivatives was
prepared starting from pyridine 1. Compound 1 on reaction with sulphuric acid gave
compound 2 which on chlorination followed by hydrazine hydrate and obtained compound
3 and 4. Compound 4 on reaction with diverse substituted aliphatic and aromatic
acid chlorides produced amide derivatives 4a-h and 5a-h.
All the final compounds were evaluated for anti cancer activity against four human
cancer cell lines such as HeLa - Cervical cancer (CCL-2); COLO 205- Colon cancer
(CCL-222); HepG2- Liver cancer (HB-8065); MCF7 - Breast cancer (HTB-22). Promising
compounds 4f and 4g were identified.
