Research Journal of Chemistry

and Environment


Indexed in SCOPUS, Chemical Abstracts, UGC, NAAS, Indian Citation Index etc.



Please donate Rs.7000/- per plant to WRA for our plantation drive of planting 50,000 trees for a better environment and oblige.



WRA Plantation - 40,000 trees grown on rocks and stones on barren rocky hillock "Keshar Parvat".






Review Paper:

Navigating CKD Diagnosis: Biomarkers as Predictive Tools for Early Detection

Devi Chingtham Henthoibi and Kosey Sourabh

Res. J. Chem. Environ.; Vol. 29(3); 148-158; doi: https://doi.org/10.25303/293rjce1480158; (2025)

Abstract
The prevalence of CKD worldwide is a significant health concern, considering its estimated incidence in 13.4% of the world population and millions who require renal replacement therapy. This review about early CKD detection by traditional biomarkers like GFR and albuminuria focuses on the importance of this issue, mainly due to the limitations of these indicators, particularly in early CKD stages. The review promises several new emerging biomarkers like beta-trace protein, or BTP, beta-2-microglobulin, or B2M, klotho, neutrophil gelatinase-associated lipocalin, or NGAL and liver-type fatty acid-binding protein, or L-FABP. Such markers would identify kidney dysfunction, tubulointerstitial damage and endothelial dysfunction more promptly and are thus crucial for improved patient outcomes.

While these advances will eventually take place in the standardization of the use of biomarkers for clinical practice, especially in resource-limited settings, where this overdiagnoses and overtreats. It also makes it difficult to have a "universal" gold standard of biomarkers for early CKD, thus making validation and implementation difficult. Future studies should validate these biomarkers in terms of their cost-effectiveness and long-term consequences in the management of CKD and patient care.