Extraction of
Barleria prionitis (root) and evaluation of tyrosinase inhibition activity
Thailan V., Parvadhavardhani M., Geethalakshmi M. and Jayashree S.
Res. J. Biotech.; Vol. 20(4); 33-40;
doi: https://doi.org/10.25303/204rjbt033040; (2025)
Abstract
The present study evaluated the tyrosinase inhibition activity and antioxidant activity
for Vitiligo (pale white patches) disease by using Barleria prionitis (root) extracts
with solvent extracts of ethyl acetate. The tyrosinase inhibition activity of the
extracts was determined by inhibition concentration (IC50 values). Results showed
that ethyl acetate had the highest tyrosinase inhibition activity by decreasing
the percentage of inhibition concentration. The extracts' antioxidant activities
were assessed by scavenging 1,1-diphenyl-2- picrylhydrazyl radicals (DPPH test).
The results showed that ethyl acetate root extract of Barleria prionitis has a higher
antioxidant activity which proved that it strongly helps to tyrosinase inhibition
activity. The findings indicate that extract from ethyl acetate has the strongest
tyrosinase inhibitory activity which helps to increase melanin pigmentation in Vitiligo
disease affected patients.
