Towards effective
advance treatment Strategies: Screening and synergism analysis of drug combinations
for Alzheimer’s disease
Desai Divyata and Mishra Kundan Kumar
Res. J. Biotech.; Vol. 20(8); 25-42;
doi: https://doi.org/10.25303/208rjbt025042; (2025)
Abstract
Alzheimer's disease (AD) remains a significant challenge in modern medicine due
to its progressive cognitive decline and the absence of effective treatments. This
neurodegenerative disorder is characterized by the accumulation of amyloid β protein
(Aβ) and the formation of neurofibrillary tangles. Molecular docking, a computational
technique, has emerged as a powerful tool in drug discovery by predicting ligand-receptor
interactions. Virtual high throughput screening (vHTS) facilitates the rapid evaluation
of potential drug candidates against AD-associated targets. Given the complexity
of aging mechanisms implicated in AD, a multi-target strategy has garnered attention
as a promising approach. Combination therapy utilizing existing medications offers
a cost-effective alternative to traditional drug development.
In this study, the synergistic effects of specific drug combinations including N-acetyl
cysteine + Curcumin, Mitoquinone + Butylated hydroxy anisole and Carnosine + Kynurenic
Acid Cocktail of Drugs, were evaluated against AD using Compusyn software. Understanding
the synergism, antagonism and additive effects of these combinations provides insights
into potential therapeutic avenues for AD. This integrated approach combining computational
modelling, drug screening and combination therapy represents a promising strategy
in the quest for effective AD treatments.
