Microbial and
antioxidant efficacy of bimetallic copper-zinc nanoparticle using leaf extract of
Lantana camara
Bhatti Laxmi and Khatak Sunita
Res. J. Biotech.; Vol. 20(12); 167-176;
doi: https://doi.org/10.25303/2012rjbt1670176; (2025)
Abstract
Nanotechnology is becoming increasingly popular and it is currently a well-established
subject of interdisciplinary science. Nanoparticles can be manufactured using a
variety of processes, but they have a few disadvantages including toxicity. To circumvent
the limits of traditional synthesis processes, the attention has switched to a new
radius that includes biological entities such as plants, known as green synthesis.
Nanotechnology is one of the most important areas of research for the development
of environmentally friendly biological processes for nanoparticle synthesis. Copper-Zinc
nanoparticles (Cu-Zn NPs) were synthesised at ambient temperature with leaf extract
of Lantana camara acting as the reducing agent. Aqueous methanolic extracts were
used to perform qualitative screening of phytochemical components which revealed
the presence of glycosides, alkaloids, tannins, terpenes, flavonoids, saponins and
carbohydrates. Cu, Zn and Cu-Zn NPs were designed with the aim of scavenging free
radicals and functioning as antibacterial static agents. Biosynthesized NPs were
found to be more effective DPPH radical scavengers than aqueous leaf extract.
Furthermore, the biosynthesized nanoparticles effectively reduced the growth of
therapeutically relevant pathogenic Gram-positive bacteria (Staphylococcus aureus,
Bacillus cereus, Candida albicans and Bacillus subtilis) as well as Gram-negative
bacteria (E.coli and Pseudomonas aeruginosa). According to the study, biosynthesized
nanoparticles have a great potential for use in the creation of medications used
to treat a variety of ailments, as well as being a prospective contender for numerous
medicinal applications.
