Anti-hypercholesterolemic
Effect of Ethanol Fruit Extract of Ficus racemosa L.
Patimah and Dodi Irwandi
Res. J. Biotech.; Vol. 20(3); 92-95;
doi: https://doi.org/10.25303/203rjbt092095; (2025)
Abstract
The objective of the study was to examine the impact of the ethanol extract of Ficus
racemosa L fruit on rats with hypercholesterolemia. The rats were divided into distinct
groups and were administered varying doses of the extract or simvastatin. Hypercholesterolemia
was induced in the rats, and the lipid profiles were measured at both the pre- and
post-treatment stages. The findings demonstrated that the Ficus racemosa L fruit
extract markedly reduced total cholesterol and triglyceride levels while elevating
HDL levels in the hypercholesterolemic rats.
The 500 mg/kg dose demonstrated the most promising outcomes, exhibiting a notable
reduction in cholesterol and triglycerides and an increase in HDL. However, no impact
on weight loss was observed. These findings indicate that Ficus racemosa L fruit
extract may have the potential to be utilized in the management of hypercholesterolemia,
although further investigation is necessary to elucidate the underlying mechanisms
of action.
