Association of
rs2228570 and rs11568820 polymorphisms in the Vitamin D Receptor gene with breast
cancer risk in Vietnamese women
Thanh Thi Ngoc Nguyen and Hue Thi Nguyen
Res. J. Biotech.; Vol. 20(5); 35-39;
doi: https://doi.org/10.25303/205rjbt35039; (2025)
Abstract
Recent research has increasingly concentrated on the potential correlation between
breast cancer risk and vitamin D, particularly focusing on the vitamin D receptor
(VDR) gene. The VDR gene's polymorphisms including rs2228570 (Fok1) and rs11568820
(Cdx2), have been implicated in modifying breast cancer susceptibility, though findings
vary across populations. This study investigates the association of these VDR polymorphisms
with breast cancer risk in Vietnamese women. A case-control study involving 100
breast cancer patients and 100 healthy controls was conducted, with genomic DNA
isolated and SNP genotyping performed. The results revealed a significant protective
effect of the rs2228570 (Fok1) SNP under the overdominant model (AG vs. AA + GG)
with an odds ratio (OR) of 0.52, indicating statistical significance (p-value =
0.03).
In contrast, rs11568820 (Cdx2) showed no significant association with breast cancer
risk across all genetic models analyzed. Although haplotype analysis did not reveal
any significant associations, the AT haplotype exhibited a non-significant trend
toward increased risk relative to the reference haplotype (OR = 1.56, 95% CI: 0.89–2.75,
p-value = 0.1231). These findings highlight the importance of considering population-specific
genetic factors in breast cancer risk assessment and underscore the need for further
research to understand these complex genetic associations fully.
