Review Paper:
Bioprospecting
Actinomycetes from the Rhizosphere of Piper nigrum: Potential and Challenges
Balaji Muralikrishnan, Senthil Kumar J. and Ashwini Malla
Res. J. Biotech.; Vol. 20(11); 395-401;
doi: https://doi.org/10.25303/2011rjbt3950401; (2025)
Abstract
This prospective review explores the biotechnological potential of actinomycetes
isolated from the rhizospheres of Piper nigrum L. which is commonly known as black
pepper. Actinomycetes are Gram-positive filamentous bacteria that are well known
for their ability to produce a plethora of bioactive compounds, including antibiotics.
The rhizosphere, a nutrient-rich zone surrounding plant root, offers a unique microenvironment
that fosters the growth of diverse actinomycetes with unique metabolic capabilities.
This review underscores the significance of these microorganisms in soil ecosystems,
highlighting their crucial role in the discovery of novel antibiotics in the context
of rising antimicrobial resistance.
Furthermore, it delves into the challenges associated with bioprospecting actinomycetes
including difficulties in isolation and cultivation, genetic manipulation and the
complex, time-intensive pipeline required to develop and commercialize new antibiotics.
Through addressing these challenges, this review provides insights into improving
strategies for harnessing the full potential of rhizosphere actinomycetes in antibiotic
discovery.
