Electrospun gelatin
sheet reinforced with anti-hypertensive drug for wound healing application
Murugan Sanjuna, Mubeena S., Somasundaram Shanmathy, Punnoose Alan M. and Raghavendran
Hanumantha rao Balaji
Res. J. Biotech.; Vol. 20(10); 143-148;
doi: https://doi.org/10.25303/2010rjbt1430148; (2025)
Abstract
Testing the potential of an electrospun fibrous sheet made with gelatin loaded with
the ACE angiotensin converting enzyme inhibitor perindopril (PE-G) was the aim of
the investigation. Physico-chemical property analysis was done utilizing Fourier
transmission infrared spectroscopy (FTIR), X-ray diffraction (XRD) and Scanning
electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDX). Cell migration
properties of PE-G in comparison to gelatin scaffold are employing dermal fibroblast
cells in vitro. The porosity pattern of the non-woven gelatin sheet was not altered
in 1% PE-G, but it was by 3% and 5% PE-loaded gelatin without changes in the elements.
FTIR measurements verified the existence of PE and gelatin functional groups in
the PE-G scaffold. According to XRD examination, the PE-G fibrous sheet's percentage
of crystalline and amorphous nature was altered. Compared to PE-loaded fibrous sheets,
gelatin showed a significant cell migratory population. PE-loaded gelatin may be
a good option for wound healing applications.
