Exploring the
Therapeutic Potential: Investigating the Synthesis, Characterization and in vitro
Anti-Diabetic Efficacy of Silver Nanoparticle Ethanolic Extract from Boerhavia diffusa
Reena Joy A., Gayathri Devi S., Samuel Slade, Vasundhara C.C.S. and Priyadharshini
M.S.
Res. J. Biotech.; Vol. 20(10); 296-304;
doi: https://doi.org/10.25303/2010rjbt2960304; (2025)
Abstract
Many studies explore the effects of Boerhavia diffusa (Bd) combined with synthesized
silver-nanoparticles extract (AgNPs) for treating a variety of conditions, although
rarely for diabetes. To address this, we investigate the inhibitory effect of BdAgNPs
in standard in vitro antidiabetic assays using the whole plant extract dissolved
in ethanol (EBdAgNPs). EBdAgNPs was characterized by UV-Visible, XRD and FT-IR spectroscopy
techniques. The assays consisted of α-amylase, α-glucosidase, protein glycation,
non-enzymatic glycosylation of hemoglobin, glucose uptake by yeast and glucose diffusion.
The formation of AgNPs was revealed by observing a surface Plasmon resonance peak
at 410 nm.
Notably, EBdAgNPs exhibited robust inhibitory effects in comparison to standard
control drugs within the assays. These compelling findings strongly indicate the
potential of EBdAgNPs as a viable avenue for treating diabetes mellitus. Further
clinical investigations are warranted to fully explore EBdAgNPs potential in novel
therapeutic approaches for managing diabetes and related conditions.
