Green synthesis
of magnesium nanoparticle using Mangifera indica seed extract and its anti-cancer
activity
Rajeswari A., Gopukumar S.T. and Saranyadevi S.
Res. J. Biotech.; Vol. 20(10); 230-240;
doi: https://doi.org/10.25303/2010rjbt2300240; (2025)
Abstract
The World Health Organization established that cancer is a contributing factor to
death in many patients below the age of 70, this calls for the development of better
treatment methods. Conventional therapies involving cancer are chemotherapy, radiation
therapy, and immunotherapy and have problems like low solubility, high toxicity,
and non-target specific cytotoxicity. The research focuses on using metallic nanoparticles
for cancer treatment by taking advantage of two unique features associated with
the optical properties, biocompatibility, and flexibility in the functionalization
of nanoparticles over conventional therapies. This study suggests that improved
indigenous treatments are necessary to reduce the illness. Cervical, oral, and colorectal
cancers are the most common tumors in women, with breast cancers accounting for
most cases.
Mangifera indica seed extract was utilized for the green synthesis of magnesium
nanoparticles. The formation of magnesium nanoparticles was further confirmed by
Ultraviolet-visible spectrophotometry, Fourier-transform infrared spectroscopy,
X-ray diffraction, Scanning electron microscopy, and Dynamic Light Scattering. In
the present study, anticancer activity was assessed using the HT-29 cell line and
the result revealed that IC50 was 33.24 μg/ml for magnesium nanoparticles. At the
same time, the actual standard has been 6.88 μg/ml. It can be concluded that the
synthesized magnesium nanoparticles have a powerful anticancer activity that makes
them promising for further clinical applications.
