In silico and
in vitro Antimicrobial Assessment of Oroxylum indicum (L). Kurz stem bark extract
against four Bacterial and Fungal Species
Sushma, Mohanraj Roshni Juliet, Bhat Nanditha, Revanasiddappa Bistuvalli Chandrashekharappa
and Sharmila Kameyanda Poonacha
Res. J. Biotech.; Vol. 20(10); 241-249;
doi: https://doi.org/10.25303/2010rjbt2410249; (2025)
Abstract
In the present study, we used oroxylum indicum (OI) a traditional medicinal plant
stem bark extract to evaluate its antimicrobial and anti-inflammatory properties.
The antibacterial and antifungal properties of Oroxylum indicum stem bark extract
were assessed by well diffusion assay. Further, the anti-inflammatory property of
OI stem bark extract was evaluated using egg albumin denaturation and bovine serum
albumin denaturation assays. The cytotoxicity was evaluated by MTT assay.
The OI extract showed antibacterial activity against Staphylococcus aureus, Pseudomonas
aeruginosa, Escherichia coli exhibiting the maximum zone of inhibition. From the
results of antifungal activity, it was evident that the OI stem bark extract showed
maximum zone of inhibition against the test organisms namely, Aspergillus niger,
Aspergillus flavus, Aspergillus fumigatus and Penicillium citricus. From our study
findings, it is evident that OI stem bark extract has the potential to be used for
treating bacterial and fungal infection.
