Structural and
Physico-chemical Analysis of the Matrix Protein of Nipah Virus (NiV): Implications
for Drug Design
Sohpal Vipan K. and Gill Gurleen
Res. J. Biotech.; Vol. 20(10); 65-68;
doi: https://doi.org/10.25303/2010rjbt065068; (2025)
Abstract
The Nipah virus, a zoonotic pathogen with high mortality rates, poses a significant
public health concern. This research focuses comprehensive analysis of its structural
and physico-chemical properties, this study aims to contribute valuable insights
for drug design and therapeutic interventions. The matrix protein's amino acid sequence
was accessed and subjected to physicochemical characterization, revealing stable
features with an instability index of 29.53 and a high aliphatic index of 90.26.
Secondary structure prediction using SOPMA indicated a prevalence of random coils
(51.70%), while PHYRE 2 provided additional insights into disorder prediction.
Homology modeling through Swiss Model generated a three-dimensional structure, exhibiting
good stereochemical quality validated by a Ramachandran plot. Approximately 92.2%
of residues were located in favourable regions, indicating the reliability of the
predicted model.
