An investigation
of the Syzygium cumini L. seed extract against ovarian cancer: In vitro studies
Chandrasekaran Rajkuberan, Palani Selvakumari, Natarajan Kruthiga, Aasaithambi Kalaiselvi
and Sangilimuthu Alagar Yadav
Res. J. Biotech.; Vol. 20(9); 64-74;
doi: https://doi.org/10.25303/209rjbt064074; (2025)
Abstract
Medicinal plants nurture various chemical constituents that can be extracted and
used for various ailments like anticancer, antibacterial, anti-diabetic, anti-inflammatory
and antioxidants. In this pipeline, we explore the anticancer activity of Syzygium
cumini L. seed extracts against ovarian cancer. Our study shows that Syzygium cumini
L. seed extract triggers apoptosis-mediated cell death in the SKOV cell line. Further,
we uncovered that Syzygium cumini L. seed extract triggers ROS and induces oxidative
stress followed by apoptosis. The cell cycle distribution analysis by flow cytometry
denotes that Syzygium cumini L. seed extract arrests the cell cycle at the Go/G1
phase. The GC-MS analysis of the Syzygium cumini L. seed acetone extract implies
the presence of notorious bioactive compounds claiming to have antioxidant, antibacterial,
antifungal and antioxidant, anticancer and anti-inflammatory properties. Thus, in
the overall study we conclude that Syzygium cumini L. seed extract can be developed
as a lead molecule for the treatment of ovarian cancer after subjecting to in vivo
studies.
