Exploration of
bioactive compounds from marine derived Streptomyces coelicolor strain KR23 for
insights into antimicrobial potential and secondary metabolite profiling
Kiruthiga R., Bharathidasan R. and Thiruneelakandan G.
Res. J. Biotech.; Vol. 20(9); 265-270;
doi: https://doi.org/10.25303/209rjbt2650270; (2025)
Abstract
This research examines the antimicrobial efficacy of Actinomycetes procured from
marine sediment specimens, with a particular emphasis on the Streptomyces coelicolor
strain KR23. The phylogenetic assessment, predicated on 16S rRNA gene sequencing,
indicated that the isolated strain exhibits a close phylogenetic relationship with
S. coelicolor, a species renowned for its extensive biosynthetic and metabolic functionalities.
The extraction of bioactive compounds was conducted utilizing ethyl acetate and
antimicrobial evaluations revealed considerable activity against a variety of bacterial
pathogens including Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa,
Staphylococcus aureus and Streptococcus pyogenes. The analysis via Gas Chromatography-Mass
Spectrometry (GC-MS) discerned crucial bioactive compounds such as 2-phenylacetamide,
succinic acid, plicamycin, uric acid, Gentamicin and l-tyrosine butyl ester.
These compounds, which demonstrate a spectrum of action mechanisms, underscore the
potential of S. coelicolor strain KR23 as a significant resource for the innovation
of novel antimicrobial agents. Additional investigations are warranted to elucidate
the synergistic interactions of these compounds and their implications in addressing
antibiotic-resistant bacterial strains.
