Synthesis and
Antimicrobial Activities of Novel 1,2,4-Triazole Clubbed Pyrazole Derivatives
Rathod Ajay, Hadiya Akhil, Ashvin Hadiyal and Dhakhda Suresh
Res. J. Chem. Environ.; Vol. 29(8); 74-79;
doi: https://doi.org/10.25303/298rjce074079; (2025)
Abstract
A new series of 2-((4-ethyl-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-1-(3-(4-subphenyl)-5-(sub.phenyl)-4,5-dihy
dro-1H-pyrazol-1-yl)ethan-1-one derivatives (6a-6j) have been synthesized from 4-ethyl-5-phenyl-4H-1,2,4-triazole-3-thiol
and 2-chloro-1-(4,5-dihydro-5-(3-aryl)-3-arylpyrazol-1-yl)ethanone (5a-5j) in the
presence of anhydrous K2CO3. All novel compounds (6a-6j) have been characterized
by spectroscopy techniques such as 1HNMR, 13CMR, FTIR and LCMS.
All newly synthesized derivatives were investigated for their antimicrobial activity
against Gram-positive and Gram-negative bacterial strains as well as fungal strains.
Compound 6j possessing methoxy and nitro group has shown highest antibacterial activities
while 3,4 di methoxy and methyl bearing compound 6g displayed excellent antifungal
activities.
