Synthesis, Characterization
and Biological Activity of Some Chalcone Derivatives derived from 1-(2-(benzyloxy)-5-bromo-4-methoxyphenyl)ethanone
Suthar Sangita M. and Shah Sanjay S.
Res. J. Chem. Environ.; Vol. 29(12); 63-74;
doi: https://doi.org/10.25303/2912rjce063074; (2025)
Abstract
Chalcones are a noteworthy part of medicinal chemistry in the 21st century because
of their various biological activities due to the presence of , -unsaturated carbonyl
system. In this study, various novel chalcone derivatives (SCH-1 to SCH-4) were
synthesized in the presence of a base catalyzed by Claisen-Schmidt condensation
from 1-(2-(benzyloxy)-5-bromo-4-methoxyphenyl)ethanone (S-1) and various benzaldehyde
derivatives. These synthesized compounds were characterized by Fourier Transform
– Infrared Spectroscopy (FT-IR), Nuclear Magnetic Resonance (1H NMR and 13C NMR)
and Mass spectrometry.
The synthesized products undergo in vitro biological activities like antibacterial
and antifungal by the broth dilution method. SCH-1 and SCH-2 exhibit moderate activity
against Gram-positive and Gram-negative bacteria, respectively. Moreover, antifungal
activity gives different results among which compounds S-1, SCH-1 and SCH-4 show
notable antifungal activity.
