Review Paper:
Harnessing of
Chalcones in Cancer Therapy
Huq Sabereen, Devi Laishram Elizabeth, Thiruvengadam Sriram, Janhavi M.S., Dabburu
Kumaraswamy and Khan Abida
Res. J. Chem. Environ.; Vol. 29(9); 182-189;
doi: https://doi.org/10.25303/299rjce1820189; (2025)
Abstract
Cancer is a leading global health concern, causing millions of deaths annually.
It results from uncontrolled cell proliferation, often driven by genetic mutations.
Chalcones, a subclass of flavonoids, have emerged as potential anticancer agents
due to their modifiable chemical structure and diverse biological activities. Studies
have demonstrated their effectiveness against various cancer cell-lines including
MCF-7 and Caco-2, with certain derivatives acting as potent enzyme inhibitors. Given
their promising anti-proliferative properties, chalcones hold significant potential
for the development of novel anticancer drugs and overcoming drug resistance. This
review is needed to consolidate recent advancements, to explore novel chalcone derivatives
and to assess their clinical relevance, providing a deeper understanding of their
role in cancer treatment and potential health risks. This study explores chalcones
potential as anticancer targets, highlighting their molecular mechanisms. It examines
natural sources of chalcones, focusing on key compounds like butein, curcumin and
xanthohumol with significant anticancer properties.
The review also covers synthetic chalcones and chalcone hybrids, emphasizing structure
modifications for enhanced efficacy. Furthermore, it evaluates their role in overcoming
drug resistance and bioavailability challenges, offering a comprehensive perspective.
Given the rising interest in natural and synthetic bioactive compounds, this review
is essential for guiding future research and drug development. By consolidating
diverse findings, it provides a critical update on chalcones’ therapeutic potential,
aiding in the discovery of more effective anticancer treatments.
