Synthesis of metal-bis-(β-diketones)
complexes and anti-microbial evaluation study
Mohobe Pooja, Pandhurnekar Chandrashekhar, Pandhurnekar Himani and Bhattacharya
Doyel
Res. J. Chem. Environ.; Vol. 30(1); 20-30;
doi: https://doi.org/10.25303/301rjce020030; (2026)
Abstract
In the present work, β-diketone ligands, namely, 1-(2,4-dihydroxy-5-nitrophenyl)-3-p-tolylpropane-1,3-dione,
were synthesized. Different metal transition complexes for cobalt (II), nickel (II),
manganese (II), copper (II) and zinc (II) have been successfully synthesized. The
β-diketone ligand is afforded by the Baker–Venkataraman rearrangement of 4-hydroxy-5-nitro-2-p-tolyloxyacetophenone.
The synthesized ligands were characterized by elemental analysis, Fourier transform
infrared (FT-IR) spectroscopy, 1H-nuclear magnetic resonance (1H-NMR) spectroscopy
and mass spectrometry for structural confirmation. All the newly synthesized metal
complexes were characterized by their physical properties, elemental analyses, FT-IR
spectra, electronic and magnetic spectra and thermogravimetric analysis. The obtained
results show that the newly synthesized materials are stable and have decomposition
temperatures in the range of 420–570 0C.
Furthermore, to analyze their microbial potency, the antibacterial activity of the
newly synthesized metal complexes was tested against Gram-positive (Bacillus subtilis
and Staphylococcus aureus) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa
and Proteus vulgaris) bacterial strains. Some of the complexes have shown promising
activities against specific bacterial strains; thus, it can be concluded that metal
complexes with β-diketones can be used as antimicrobial agents in the future.
